【Abstract】Objective To determine the factors correlated to coronary artery calcification in very old elderly male patients with chronic kidney disease (CKD). Methods A total of 126 very old male CKD patients (≥80 years old) at stages 3 to 5 who did not receive dialysis therapy admitted in Chinese PLA General Hospital from January 2011 to December 2012 were enrolled in the study, and then stratified into 3 groups based on their glomerular filtration rate (GFR): group A [30≤GFR＜60ml/(min·1.73m2)], group B [15≤GFR＜30ml/(min·1.73m2)] and group C [GFR＜15ml/(min·1.73m2)]. Quantification of coronary artery calcification was determined by multi-slice spiral computed tomography (MSCT) for coronary artery calcification score (CACS). The relationship of coronary artery calcification to risk factors was analyzed retrospectively. Results Compared with groups B and A, the prevalence of myocardial infarction and cerebral infarction was significantly higher in group C (P＜0.05), and so were the serum level of phosphorus [(1.74±0.56) vs (1.52±0.39) vs (1.38±0.42)mmol/L, P＜0.01 or P＜0.05], and the calcium-phosphorus product [(46.32±14.36) vs (40.08±10.21) vs (38.26±13.28), P＜0.05], and CACS [(438.56±63.22) vs (316.82±77.30) vs (262.50±81.92), P＜0.01 or P＜0.05]. Spearman correlation analysis showed that CACS was positively correlated with age (r＝0.2218, P＜0.05), serum level of phosphorus (r＝0.2313, P＜0.05) and calcium-phosphorus product (r＝0.2450, P＜0.05), but negatively with body mass index (r＝-0.1956, P＜0.05) and GFR (r＝-0.4462, P＜0.01). Conclusion The prevalence of coronary artery calcification is high in very old male CKD patients. Age, body mass index, renal function and disturbance of calcium and phosphorus metabolism are correlated with the severity of coronary artery calcification.
