骨质疏松和动脉硬化共同机制的研究进展

Common mechanism of osteoporosis and arteriosclerosis: a review of recent advances

【摘要】骨质疏松和动脉硬化都属于受多因素影响，伴随着衰老的退行性疾病。越来越多的研究证明二者之间存在联系。近年来，有许多关于骨质疏松和动脉硬化共同发病机制的研究，并提出骨-血管轴的概念，即骨质疏松和血管钙化。热点机制研究主要包括RANK/RANKL/OPG系统、氧化的脂质、成纤维细胞生长因子23/Klotho轴、胎球蛋白A和循环的钙化细胞，本文对其进行综述。

基金项目:国家重点基础研究发展计划基金（2007CB507405; 2013CB530804）; 辽宁省科学技术厅课题基金（No.2007225004）

【Abstract】Osteoporosis and arteriosclerosis are both multifactorial, degenerative diseases that accompany aging. Many studies have suggested associations between osteoporosis and arteriosclerosis. In recent years, there are many studies investigating the common pathogenetic pathways of osteoporosis and arteriosclerosis. The meaning of bone-vascular axis is the associations between osteoporosis and vascular calcification. The hot research topics include RANK/RANKL/OPG system, oxidized lipids, fibroblast growth factor-23/Klotho axis, fetuin-A, and circulating calcifying cells. In this paper, we summarized the above pathogentic pathways.