在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
主 编 范利
执行主编 陈韵岱
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王欣,穆志静,孙丽娜,修双玲.老年2型糖尿病患者骨质疏松与肌少症的相关性[J].中华老年多器官疾病杂志,2022,21(1):11~14
老年2型糖尿病患者骨质疏松与肌少症的相关性
Correlation between osteoporosis and sarcopenia in elderly patients with type 2 diabetes mellitus
投稿时间:2021-04-19  
DOI:10.11915/j.issn.1671-5403.2022.01.003
中文关键词:  老年人  骨质疏松  肌少症  2型糖尿病
英文关键词:aged  osteoporosis  sarcopenia  type 2 diabetes mellitus This work was supported by the Beijing Municipal Administration of Hospitals Incubating Program
基金项目:北京市属医院科研培育计划项目(PX2020034);北京市属医学科研院所公益发展改革试点项目(京医研2021-8)
作者单位E-mail
王欣 首都医科大学第一临床医学院,北京 100053 xiushuangling@126.comcorrelation 
穆志静 首都医科大学 宣武医院内分泌科,北京 100053 xiushuangling@126.comcorrelation 
孙丽娜 首都医科大学 宣武医院内分泌科,北京 100053 xiushuangling@126.comcorrelation 
修双玲 首都医科大学 宣武医院内分泌科,北京 100053 xiushuangling@126.comcorrelation 
摘要点击次数: 218
全文下载次数: 170
中文摘要:
      目的 探讨老年2型糖尿病(T2DM)患者骨质疏松与肌少症的相关性。方法 选择2017年5月至2019年7月于首都医科大学宣武医院内分泌科住院的579例年龄≥60岁的T2DM患者为研究对象,测量患者腰椎、左股骨颈及左全髋骨密度(BMD);测量糖化血红蛋白(HbA1c)、握力与步速、四肢骨骼肌质量(ASM),计算四肢骨骼肌质量指数(ASMI)。按照患者是否发生骨质疏松和肌少症分别将患者分为骨质疏松组(180例)和非骨质疏松组(399例),肌少症组(52例)和非肌少症组(527例),分析骨质疏松与肌少症的相关性。采用SPSS 24.0统计软件进行数据分析。根据数据类型,分别采用t检验、Mann-Whitney U检验或χ2检验进行组间比较。采用多元logistic回归分析肌少症与骨质疏松的相互影响。结果 肌少症组体质量指数(BMI)、左股骨颈与左全髋的BMD和T值均显著低于非肌少症组(P<0.05);骨质疏松组BMI、ASMI、握力、步速均显著低于非骨质疏松组(P<0.05)。多元logistic回归分析显示,老年T2DM患者肌少症为骨质疏松的危险因素(OR=2.16,95%CI 1.131~4.125,P=0.02),骨质疏松为肌少症的危险因素(OR=2.27,95%CI 1.121~4.596,P=0.023)。结论 老年T2DM患者骨质疏松与肌少症有相互促进作用。
英文摘要:
      Objective To investigate the correlation between osteoporosis and sarcopenia in elderly patients with type 2 diabetes mellitus (T2DM). Methods Totally 579 patients aged ≥60 years with T2DM were enrolled from the Department of Endocrinology of Xuanwu Hospital. Bone mineral density (BMD) of lumbar vertebrae, left femoral neck and left total hip were measured. Hemoglobin A1c (HbA1c), appendicular skeletal muscle mass (ASM), grip strength and walking speed were also measured. The appendicular skeletal muscle mass index (ASMI) was calculated. The participants were divided into two groups according to osteoporosis and sarcopenia, with 180 cases in osteoporosis group and 399 cases in nonosteoporosis group, 52 cases in sarcopenia group and 527 cases in nonsarcopenia group. The correlation between osteoporosis and sarcopenia was assessed. SPSS 24.0 was used for data analysis. According to the different data type, t-test, Mann-Whitney U test or χ2 test was used for comparison between groups. Multivariate logistic regression was used to analyze the association between sarcopenia and osteoporosis. Results Body mass index (BMI), BMD and T values of left femoral neck, left total hip in the sarcopenia group were significantly lower than those in the nonsarcopenia group (P<0.05). BMI, ASMI, grip strength and walking speed in the osteoporosis group were significantly lower than those in the nonosteoporosis group (P<0.05). Multiple logistic regression analysis showed that sarcopenia was a risk factor for osteoporosis (OR=2.16,95%CI 1.131-4.125, P=0.02) and that osteoporosis was a risk factor for sarcopenia (OR=2.27,95%CI 1.121-4.596, P=0.023) in old adults with T2DM. Conclusion Osteoporosis and sarcopenia can interplay each other in the elderly patients with T2DM.
查看全文    下载PDF阅读器
关闭