在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
吕彦泽,吴雅婷,郑月宏.血管周围脂肪组织与衰老相关血管疾病研究进展[J].中华老年多器官疾病杂志,2021,20(12):919~923
血管周围脂肪组织与衰老相关血管疾病研究进展
Research progress of perivascular adipose tissue and aging related vascular diseases
投稿时间:2021-05-25  
DOI:10.11915/j.issn.1671-5403.2021.12.194
中文关键词:  血管周围脂肪组织;衰老;动脉粥样硬化
英文关键词:perivascular adipose tissue;aging;vascular diseases This work was supported by the Major Research Program of Natural Science Foundation of China
基金项目:国家自然科学基金重大项目(51890894);国家自然科学基金面上项目(81770481,2070492)
作者单位E-mail
吕彦泽 中国医学科学院北京协和医院 血管外科,北京 100730 yuehongzheng@yahoo.comresearch 
吴雅婷 中国医学科学院北京协和医院 神经内科,北京 100730 yuehongzheng@yahoo.comresearch 
郑月宏 中国医学科学院北京协和医院 血管外科,北京 100730 yuehongzheng@yahoo.comresearch 
摘要点击次数: 15
全文下载次数: 25
中文摘要:
      血管周围脂肪组织(PVAT)是围绕血管的一种特殊脂肪组织,是血管内稳态的重要调节者,它除了支持组织的作用外,也是一个内分泌器官,在衰老过程中可导致血管功能失调。PVAT可释放多种脂肪细胞因子、趋化因子和生长因子,这些PVAT衍生因子以内分泌和旁分泌的方式调节血管信号和血管功能。在生理条件下,PVAT能够储存和燃烧脂质,产生热量,并从血液中吸收脂肪酸。PVAT还可释放多种血管活性分子,如NO、H2S和脂联素等,防止动脉粥样硬化的发展。同时PVAT在动脉粥样硬化的发展过程中起着关键的作用。肥胖、2型糖尿病、血管损伤和衰老等病理条件可导致PVAT功能障碍、血管内皮细胞和平滑肌细胞功能障碍。主要表现为PVAT释放促炎脂肪因子,进一步引起内皮功能障碍、炎症细胞浸润和血管平滑肌细胞迁移,从而导致动脉粥样硬化的发展。PVAT被认为是年龄相关血管疾病的预测因子和潜在治疗干预的靶点。本文总结了PVAT与年龄相关血管疾病的关系,对PVAT在多种血管系统相关疾病中所起的作用进行综述。
英文摘要:
      Perivascular adipose tissue (PVAT) is an important regulator of endovascular homeostasis. It is a special adipose tissue around blood vessels. In addition to supporting tissue, it is also an endocrine organ, which can lead to vascular dysfunction in the process of aging. PVAT can release a variety of adipose cytokines, chemokines and growth factors. PVAT-derived factors regulate vascular signaling and inflammation to regulate the function of adjacent layers of the vascular system in an endocrine and paracrine manner. Under physiological conditions, PVAT can store and burn lipids, generate heat, and absorb fatty acids from the blood. PVAT can also release a variety of vasoactive molecules, such as NO, H2S and adiponectin, to prevent the development of atherosclerosis. At the same time, PVAT plays a key role in the development of atherosclerosis. When obesity, type 2 diabetes mellitus, vascular injury and aging can lead to PVAT dysfunction, vascular endothelial cell and smooth muscle cell dysfunction. The main manifestation is the release of pro-inflammatory adipokines by PVAT, which further causes endothelial dysfunction, inflammatory cell infiltration and vascular smooth muscle cell migration, thus promoting the development of atherosclerosis. PVAT is considered to be a predictor of age-related vascular diseases and a potential target for therapeutic intervention. In this review, we summarize the relationship fo PVAT with age-related vascular diseases, and the role of PVAT in different diseases related to vascular system was reviewed.
查看全文    下载PDF阅读器
关闭