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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王冠武,曹广信,刘洪涛,裴长安,张纪存,孙波,张杰峰.泡沫硬化剂聚多卡醇联合大隐静脉高位结扎剥脱术治疗D-二聚体升高静脉曲张患者的疗效[J].中华老年多器官疾病杂志,2021,20(12):915~918
泡沫硬化剂聚多卡醇联合大隐静脉高位结扎剥脱术治疗D-二聚体升高静脉曲张患者的疗效
Efficacy of foam sclerosing agent, polidocanol combined with high ligation and stripping of great saphenous vein in treatment of varicose vein patients with elevated D-dimer
投稿时间:2021-05-25  
DOI:10.11915/j.issn.1671-5403.2021.12.193
中文关键词:  静脉曲张;泡沫硬化剂;聚多卡醇;高位结扎剥脱术;D-二聚体
英文关键词:varicose veins; foam sclerosing agent; polidocanol; high ligation and stripping; D-dimer Corresponding author:ZHANG Jie-Feng, E-mail:zjf201904@qq.com〖FL
基金项目:
作者单位E-mail
王冠武 潍坊市人民医院血管外科,山东 潍坊 261041
潍坊阳光融和医院介入血管科,山东 潍坊261000 
zjf201904@qq.comefficacy 
曹广信 潍坊市人民医院血管外科,山东 潍坊 261041 zjf201904@qq.comefficacy 
刘洪涛 安丘市中医院介入中心,山东 安丘 262100 zjf201904@qq.comefficacy 
裴长安 潍坊市人民医院血管外科,山东 潍坊 261041 zjf201904@qq.comefficacy 
张纪存 潍坊市人民医院血管外科,山东 潍坊 261041 zjf201904@qq.comefficacy 
孙波 潍坊市人民医院血管外科,山东 潍坊 261041 zjf201904@qq.comefficacy 
张杰峰 潍坊市人民医院血管外科,山东 潍坊 261041 zjf201904@qq.comefficacy 
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中文摘要:
      目的 观察局部注射泡沫硬化剂聚多卡醇联合大隐静脉高位结扎剥脱术对D-二聚体升高的大隐静脉曲张患者的疗效,并随访并发症发生情况。方法 回顾性分析2020年3月至2021年2月潍坊市人民医院血管外科收治的838例大隐静脉曲张患者的临床资料,从中筛选66例术前D-二聚体指标升高的患者纳入试验组,筛选66例术前D-二聚体指标正常的患者纳入对照组,2组患者均接受大隐静脉高位结扎并剥脱术+曲张静脉聚多卡醇注射治疗。术后观察2组患者大隐静脉曲张的治疗效果及普通静脉炎、表浅血栓性静脉炎、深静脉血栓等并发症的发生情况。采用SPSS 19.0统计软件进行数据分析。根据数据类型,分别采用t检验或χ2检验进行组间比较。结果 2组患者治疗前与术后1个月CEAP评分[试验组:(2.86±1.02)和(0.97±1.48)分;对照组:(2.80±1.13)和(0.92±1.49)分]比较,差异均有统计学意义(P<0.05);但试验组和对照组术后1个月CEAP评分[(0.97±1.48)和(0.92±1.49)分]比较,差异无统计学意义(P>0.05)。试验组和对照组并发症发生率比较(59.1%和53.0%),差异无统计学意义(P>0.05)。结论 泡沫硬化剂聚多卡醇局部注射联合大隐静脉高位结扎并剥脱术治疗D-二聚体升高的静脉曲张患者,整体疗效确切且安全可行。
英文摘要:
      Objective To investigate the efficacy of local injection of foam sclerosing agent, polidocanol, combined with high ligation and stripping of the great saphenous vein and observe the incidence of complications in patients with great saphenous vein varicosity complicated with elevated D-dimer level. Methods A retrospective analysis was performed on the clinical data of 838 patients with varicose saphenous veins admitted to the Department of Vascular Surgery of Weifang People′s Hospital from March 2020 to February 2021. Then from them, 66 patients with elevated preoperative D-dimer level were selected and assigned into the study group, and another 66 patients with normal D-dimer level preoperatively were subjected into the control group. All of them received high ligation and stripping of the great saphenous vein+varicose vein injection of polidocanol. The therapeutic effect and the occurrence of common phlebitis, superficial thrombophlebitis, deep vein thrombosis and other complications were observed in the two groups after operation. SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for intergroup compa-rison depending on different data types. Results The CEAP scores [CEAP classification stands for Clinical (C), Etiology (E), Anatomy (A), and Pathology (P)] were compared between before treatment and 1 month after surgery [study group:(2.86±1.02) vs (0.97±1.48)points; control group:(2.80±1.13) vs (0.92±1.49) points], the differences were statistically significant (all P<0.05). But there were no statistical differences in the CEAP scores between the two groups 1 month after surgery (P>0.05), and no significant differences in the incidence of complications between the study group and control group (59.1% vs 53.0%) (P>0.05). Conclusion Local injection of polidocanol combined with high ligation and stripping of the great saphenous vein is a safe and feasible treatment for varicose veins complicated with elevated D-dimer.
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