血管生成素在中枢神经系统损伤中的研究进展
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南京医科大学附属江宁医院骨科

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江苏省自然科学基金


Research progress of angiopoietin in central nervous system injury
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Department of Orthopedics,The Affiliated Jiangning Hospital with Nanjing Medical University

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    摘要:

    神经损伤是骨科和神经科医生的棘手问题,目前尚无确切有效的治疗方法。血管生成素(angiopoietin,Ang)是一种血管生成因子,近年来,Ang的神经保护作用逐渐被发现。Ang可以通过促进新血管生成、维持血脑屏障和血脊髓屏障的稳定性、抑制神经损伤后的炎症反应和毒性离子进入神经细胞起神经保护作用。重要的是,Ang可以直接作用于神经细胞抑制损伤后细胞自噬和凋亡。本文就Ang在神经系统中的保护作用及其机制进行综述,为探索其成为新型神经保护因子提供研究思路。

    Abstract:

    Nerve damage poses a complex challenge for orthopedists and neurologists, with no definitive treatment currently available. Angiopoietin (Ang) is recognized as an angiogenic factor, and recent research has unveiled its neuroprotective properties. Ang demonstrates neuroprotective capabilities by facilitating the formation of new blood vessels, preserving the integrity of the blood-brain barrier and blood-spinal cord barrier, as well as suppressing inflammatory responses and the influx of harmful ions into nerve cells post-injury. Notably, Ang can directly impact nerve cells by inhibiting autophagy and apoptosis following injury. This review delves into the neuroprotective effects and underlying mechanisms of Ang within the nervous system, offering valuable insights for further exploration of its potential as a novel neuroprotective agent.

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  • 收稿日期:2024-04-06
  • 最后修改日期:2024-06-04
  • 录用日期:2024-06-07
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